Primarily based at Hanscom Air Force Base, Mass., with personnel at Maxwell AFB/Gunter Annex, Alabama, Joint Base San Antonio, Texas, and Wright-Patterson AFB, Ohio, this division manages a broad portfolio of the Department of the Air Force's enterprise information technology and cyber infrastructure programs. With over 900 personnel overseeing more than 100 projects, they are the Air Force's primary source for developing, delivering, and sustaining war-winning information technology, network infrastructure, and defensive cyber capabilities. Their work supports every airman and guardian across all Air Force and Space Force bases globally. This division is responsible for the Air Force network infrastructure, both within the continental United States and overseas. ​

HNI manages DAF365, which facilitates and secures mission-critical data sent via email, messaging and collaborative services. The division also leads the Air Force's cloud services provision through Cloud One, a centralized team providing Cloud Infrastructure with built-in security for Air Force, Space Force, and Department of Defense programs and weapon systems at Impact Levels 2, 4, 5, and 6. Furthermore, the division provides cutting-edge information technology through Enterprise IT as a Service, data analytics and machine learning, enterprise-wide technology as a service, and cloud-hosted enterprise services. ​